A Hill type equation can predict target gene expression driven by p53 pulsing
نویسندگان
چکیده
منابع مشابه
Regulation of p53 target gene expression by peptidylarginine deiminase 4.
Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this modification is reversed to repress the expression of p53 target genes is unclear. Here, we report that peptidylarginine deiminase 4, a histone citrullination enzyme, is involved in the repression of p53 target genes. Inhibition or depletion of PAD4 elevated the expression of a...
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The p52/p100 nuclear factor kappa B (NF-jB) subunit (NF-jB2) is aberrantly expressed in many tumour types and has been implicated as a regulator of cell proliferation. Here, we demonstrate that endogenous p52 is a direct regulator of Cyclin D1 expression. However, stimulation of Cyclin D1 expression alone cannot account for all the cell cycle effects of p52/p100 and we also find that p52 repres...
متن کاملTranscriptional pulsing and consequent stochasticity in gene expression
Transcriptional pulsing has been observed in both prokaryotes and eukaryotes and plays a crucial role in cell to cell variability of protein and mRNA numbers. The issue is how the time constants associated with episodes of transcriptional bursting impact cellular mRNA and protein distributions and reciprocally, to what extent experimentally observed distributions can be attributed to transcript...
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ژورنال
عنوان ژورنال: FEBS Open Bio
سال: 2021
ISSN: 2211-5463,2211-5463
DOI: 10.1002/2211-5463.13179